Month: August 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 202 [7-(1-Ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-(4-piperazin-1-yl-phenyl)-amine To a mixture of 4-(4-amino-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (133 mg, 0.48 mmol) and sodium tert-butoxide (57.6 mg, 0.6 mmol) in 1,4-dioxane (0.5 mL) is added a solution of 2-chloro-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine (90 mg, 0.4 mmol) in 1,4-dioxane (1.0 mL), Pd2(dba)3 (18.3 mg, 0.02 mmol) and BINAP (25 mg, 0.04 mmol). The mixture is degassed, and heated at 100 C. for 3 h. The mixture is cooled to room temperature, diluted with EtOAc, and filtered through celite. The filtrate is concentrated under reduced pressure. The residue is purified by flash chromatography (SiO2, EtOAc_Hexane=1:1) to give 167 mg of 4-{4-[7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester as a pale yellow solid.

170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; Astex Therapeutics Ltd.; US2009/318441; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

438631-77-7, (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3; 4-(5-Trifluoromethyl-pyridin-2-yl)-piperazine-l,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester :; S-Methyl-piperazine-l^-dicarboxylic acid 1-tert-butyl ester (120 mg, 0.49 mmol) and 2-Bromo-5- trifluoromethyl-pyridine (133 mg, 0.59 mmol) were dissolved in 2.0 mL of anhydrous toluene (degassed). In a separate, septum-equipped vial were placed tri(dibenzylideneacetone)dipalladium (0) (22 mg, 0.024 mmol), l,3-bis(2,6-di-J-propylphenyl)imidazolium chloride (42 mg, 0,1 mmol) and sodium ^-butoxide (57 mg, 0.59 mmol). This “catalytic” vial was equipped with a magnetic stir bar and flushed with dry nitrogen. The reactant solution was next transferred to the “catalytic” vial and the mixture was stirred at 1000C for 5 h. After this period the mixture was combined with 20 mL of hexane/EtOAc (2:1) and was passed through a pad of Celite. The resulting filtrate was evaporated in vacuo and purified using flash silica chromatography (0-20% EtOAc/Hexane) to yield 110 mg (58%) of 4-(5-TrifIuoromethyl-pyridin-2-yl)- piperazine-l,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester., 438631-77-7

The synthetic route of 438631-77-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KALYSPSYS, INC.; NOBLE, Stewart A.; OSHIRO, Guy; MALECHA, James W.; ZHAO, Cunxiang; ROBINSON, Carmen K. M.; DURON, Sergio G.; SERTIC, Michael; LINDSTROM, Andrew; SHIAU, Andrew; BAYNE, Christopher; KAHRAMAN, Mehmet; LOU, Boliang; GOVEK, Steven; WO2006/55187; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 8a-e (20 mmol) and triethylamine (40 mmol) indichloromethane (20 ml), a solution of 4a-f (1.5 eq) in dichloromethane(10 ml) was added dropwise at room temperature over20 min and stirred overnight. The mixture was washed with saturatedaqueous sodium bicarbonate and brine. After removing thesolvent under reduced pressure, the crude product was purifiedby flash chromatography on silica gel, eluting with dichloromethaneand methanol (10-30%), yielding the title compounds., 694499-26-8

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yao, Dahong; Wang, Jing; Wang, Guan; Jiang, Yingnan; Shang, Lei; Zhao, Yuqian; Huang, Jian; Yang, Shilin; Wang, Jinhui; Yu, Yamei; Bioorganic Chemistry; vol. 68; (2016); p. 112 – 123;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129779-30-2, (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4.00 g of cis-3,5-dimethylpiperazine-1-carboxylic acid ter-butyl ester (prepared according to the method E. Jon Jacobson et. al. J. Med. Chemistry. 1999, Vol. 42,1123-144) in 91 mL of dichloromethane was treated with sodium bicarbonate (4.7 g) followed by addition of cyanogen bromide (7.5 mL). The reaction mixture was heated at reflux overnight, was filtered, and was purified by column chromatography (0 to 50% ethyl acetate/hexanes) to afford 3.9 g of the title compound as a white solid. 1H NMR (CDC13, 300 MHz) delta ppm 1.33 (d, 6H, J = 6.5 Hz), 1.44 (s, 9H), 2.54 (m, 2H), 3.09 (m, 2H), 4.09 (m, 2H); 13C NMR (CDCl3, 75 MHz) 16.70 (2C), 28. 54 (3C), 53.86 (4C), 80.86, 114.10, 154.22.

129779-30-2, 129779-30-2 (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 10822535, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; CHIRON CORPORATION; GLAXOSMITHKLINE; WO2004/112793; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.,694499-26-8

General procedure: To a solution of 3-iodo-4-methylbenzoyl chloride obtained above in dry DCM (10mL) at 0C was added Et3N (0.28mL, 2.0mmol) and 4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) aniline (328mg, 1.2mmol). The mixture was stirred at room temperature for 5h, and then the solvent was removed under reduced pressure. The residue was purified by using column chromatography to afford the corresponding product 6-1 (439mg, 2 steps yield: 85%).

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Article; Liu, Yang; Peng, Xia; Guan, Xiaocong; Lu, Dong; Xi, Yong; Jin, Shiyu; Chen, Hui; Zeng, Limin; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 122 – 132;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

A. To a solution of 2-methylpiperazine (0.10 g, 1 mmol) in CH2Cl2 (2 mL) was added 4-fluorobenzyl bromide (0.125 mL, 1 mmol). The resultant mixture was stirred at ambient temperature. After 15 hours, the mixture was concentrated in vacuo to afford a solid. This solid was dissolved in CH2Cl2 and washed sequentially with water, aqueous NaHCO3 solution, then brine. The organic layer was dried over MgSO4, filtered, and concentrated to an oil. Purification by flash column chromatography afforded 0.025 g (12% yield) of 1-(4-fluorobenzyl)-3-methylpiperazine, a compound of formula (C), as a colorless oil; NMR (CDCl3) 7.3 (m, 2), 7.0 (m, 2), 3.4 (s,2), 3.0-2.6 (m, 5), 2.0 (br s, 2), 1.6 (t, 1), 1.0 (d, 3) ppm.

109-07-9, The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schering Aktiengesellschaft; US6207665; (2001); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: At first, THF (2.0 mL) was added to a mixture of oxabenzonorbornadiene 1 (0.347 mmol, 1.0 equiv), amine 4 or 6 (1.041 mmol, 3.0 equiv), NaI (10.34 mg, 0.069 mmol, 0.2 equiv), ligand L2 (4.5 mg, 0.0167 mmol, 4.8 mol %) and [Rh(C2H4)2Cl]2 (2.7 mg, 0.0069 mmol, 2.0 mol %) under N2. The mixture was then stirred at RT for 1 h and heated at reflux for 6-12 h after which the residue was subjected directly to silica gel column chromatography [ethylacetate/hexanes (1:1-2:1 v/v) as the eluent] to afford the desired alcohol product 5 or 7. The enantioselectivity was determined by chiral HPLC on a chiralcel OD-H, chiralcel AD-H, or Lux Amylose-2 column.

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Article; Luo, Renshi; Xie, Ling; Liao, Jianhua; Xin, Hu; Chan, Albert S.C.; Tetrahedron Asymmetry; vol. 25; 9; (2014); p. 709 – 717;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To the chloro compounds (1.00 mmol) in toluene, were added piperazines 8a-j (1.0 mmol) at room temperature. The reaction mixture was heated at 110 oC for overnight. After completion (TLC), the reaction mixture was extracted with ethyl acetate and water. The organic layer was separated and dried over anhydrous Na2SO4, evaporated to dryness. The residue was purified with column chromatography using an eluent of 25% ethyl acetate in hexane to furnish the compounds with moderate to good yields (64-82%)., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Banu, Saleha; Bollu, Rajitha; Naseema, Mohammad; Gomedhika, P. Mary; Nagarapu, Lingaiah; Sirisha; Kumar, C. Ganesh; Gundasw, Shravan Kumar; Bioorganic and Medicinal Chemistry Letters; vol. 28; 7; (2018); p. 1166 – 1170;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

To a suspension OF 4-METHYLPIPERAZINE-1-CARBONYL chloride hydrochloride (19.9 g 0.1 mol) and piperidone monohydrate hydrochloride (15.3 g 0.1 mol), in 200 ML of dichloromethane, dry triethylamine (45 mL, 0.33 mol) was added dropwise. The mixture was stirred for 2 hours. The organic phase was washed with brine (2 x 20 mL) and dried over sodium sulfate. After filtration, the solvent was evaporated in vacuo and the crude product was dissolved in ETOH (50 mL) and diethylether (100 mL) and treated with HCl 4N in dioxane (25 mL). After 1 hour, the precipitate was filtered and dried in oven to give 13 g (yield 50%) of the title compound. 1 H NMR (400 MHz, DMSO-D6) 8 ppm 2.40 (t, J=6. 16 Hz, 4 H) 2.81 (s, 3 H) 3.00- 3.11 (m, 2 H) 3.12-3. 23 (m, 2 H) 3.28-3. 42 (m, 2 H) 3.51 (t, J=6. 16 Hz, 4 H) 3.73 (d, J=14. 27 Hz, 2 H) 10.12 (s, 1 H), 55112-42-0

55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; PHARMACIA ITALIA S.P.A.; WO2004/104007; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 0.332/0.36885 g (0.001 mol) of 1-(6-bromohexyl)-1,8-naphthosultam(3a)/lactam (3b), 0.00095 mol of the corresponding arylpiperazine(4), 0.414/0.120 g (0.003 mol) K2CO3/NaOH and 0.032 g(0.0001 mol) of TBAB were triturated in a mortar. The triturated mixturewas transferred to a round bottom flask. In the case of the reactionin the presence of the solvent, 0.2 cm3 of acetonitrile, DMF or water wasadded to the reaction mixture. The reactions were carried out for 50 s ina CEM Discover microwave reactor at a 100W output power. Theprogress of the reaction was monitored by TLC (CHCl3:MeOH 9:1).After completion of the reaction, 40 cm3 of water was added to themixture and placed in the refrigerator overnight. After cooling, thecrude product was filtered off. In the absence of the required purity, thecrude product was crystallized from methanol or methanol-water. Afterobtaining a minimum of 90% purity, the ligands were dissolved inacetone, then converted to 4M HCl hydrochloride in dioxane. The reactionyields for individual ligands were calculated based on the weightof the obtained pure hydrochloride.

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zar?ba, Przemys?aw; Ja?kowska, Jolanta; Czekaj, Izabela; Sata?a, Grzegorz; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3396 – 3407;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics