934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 6-nitrobenzo[d]oxazole-2-thiol (KR-200) (11.63 mmol, 2.28 g) in dichloromethane (465 mL) and oxalyl chloride (14.54 mmol, 1.25 mL) was placed under argon atmosphere and cooled to 0 ?C. Dimethylformamide (12 mL) was added drop wise over a period of 40 minutes. CAUTION: The addition of dimethylformamide should be conducted slowly to avoid rapid evolution of gas. The reaction was stirred for 30 minutes at 0 ?C, then ice bath was removed and the reaction was allowed to warm to room temperature. After two hours, the reaction was again cooled to 0 ?C and triethylamine (34.90 mmol, 4.87 mL) was added drop wise over a period of 25 minutes. Then 2-(4-methylpiperazin-1-yl)ethan-1-amine (KR-251) (12.80 mmol, 1.83 g) was added, and the ice bath was removed. The reaction was stirred for sixteen hours at room temperature then concentrated in vacuo yielding a red solid. Silica gel column chromatography of the solid (10:1 dichloromethane/methanol) provided pure KR-202251 as a yellow powder in a 53percent yield.
934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various.
Reference£º
Article; Rynearson, Kevin D.; Charrette, Brian; Gabriel, Christopher; Moreno, Jesus; Boerneke, Mark A.; Dibrov, Sergey M.; Hermann, Thomas; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3521 – 3525;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics