With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
To the round bottom flask was added 3-iodo-4-methyl-benzoic acid (2.62 g, lOmmol), 10 ml of thionyl chloride and refluxed at 78 C for 4 hours. The rotary evaporator removed the volatile material to give 3-iodo- 4-methyl-benzoyl chloride. A solution of 4- (4-methylpiperazin-1-ylmethyl) -3-trifluoromethylaniline (2.27 g, 8.3 mmol), 3-iodo-4-methyl-benzoyl chloride (LOmmol), 15 ml of tetrahydrofuran, 10 ml of triethylamine and stirred at room temperature for 4 hours. Washed with saturated NaHC03 solution, extracted with ethyl acetate and water, washed with saturated NaCl solution, dried over anhydrous Na2S04, and the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column to give the title compound.
694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; NANJING SANHOME PHARMACEUTICAL CO., LTD.; WANG, YONG; ZHAO, LIWEN; CHEN, HONGYAN; ZHANG, DI; XU, XIN; ZHANG, CANG; ZHANG, HONGXING; (9 pag.)CN103664951; (2016); B;,
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