With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.
The dichloropyrimidine (2.30 gm, 6.98 X 10″3 moles) was dissolved in methylene chloride and N-methyl-N’-(2-aminoethyl)piperazine (1.0 gm, 6.98 X 10″3 moles) was added. After stirring at room temperature for 1 hour, TLC (silica, 10percent methanol in methylene chloride) showed some remaining starting material (Rf = 0.91) along with a single product (Rf = 0.32). Diisopropylethylamine (0.902 gm, 1.22 mL, 6.98 X 10″3 moles) was added and this solution was heated at 45¡ãC. for 90 minutes. After cooling, the methylene chloride was removed under reduced pressure and the remaining material was purified by chromatography on silica using 15percent methanol in methylene chloride as eluent. The fractions containing the product were pooled and evaporated to provide 2.1 gm (69percent>) of the product as an orange solid.
934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; JANUS BIOTHERAPEUTICS, INC.; LIPFORD, Grayson, B.; ZEPP, Charles, M.; WO2012/167053; (2012); A1;,
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