With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step B: tert-butyl(9aS)-3-hydroxy-3-( 1 -oxo-3.4-dihydro- 1H-isochromen-6- yl)hexahydropyrazino [2,1-c] [1,41 oxazine-8( 1H)-carboxylate: 6- (Bromoacetyl)-3 ,4-dihydro- 1H- isochromen-1-one (-.1.54 g, -.5.72 mmol, presence of cx-chloroketone was noted, -.10%) and commercially available (S)-4-N-BOC-2-hydroxymethylpiperazine (1.24 g, 5.72 mmol) were added to a round bottom flask and diluted with THF (50 mL). Diisopropylethylamine (1.30 mL,7.44 mmol) was then introduced and the mixture left stirring for 14 h at RT during which time a considerable amount of solid had formed. The reaction mixture was diluted with EtOAc, then washed with saturated NH4C1aq followed by H20. Both aqueous layers were sequentially back extracted once with another portion of EtOAc, the organics were then combined, dried with MgSO4, filtered, and concentrated in vacuo. The recovered crude product was subjected topurification by flash chromatography (Biotage, 50% EtOAc/Hex) to afford the title compound
The synthetic route of 314741-40-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DEJESUS, Reynalda, Keh; FRIE, Jessica, L.; PIO, Barbara; TANG, Haifeng; WALSH, Shawn, P.; WO2014/99633; (2014); A2;,
Piperazine – Wikipedia
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