109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 39; Synthesis of provide 4-(5-(7-methoxy-6-(2-methoxyethoxy)cinnolin-4-yl)pyridin-2-y I)-I- methylpiperazin-2-one; [00304] In a microwave vial is placed 4-(6-fluoropyridin-3-yl)-6,7-dimethoxycinnoline(0.229 mmol) in 2 ml DMSO. l-Methylrhoiperazin-2-one hydrochloride (0.3626 g, 2.29 mmol) and potassium carbonate (0.147 ml, 2.40 mmol) is added and the temperature is brought to 90 0C to stir overnight. The reaction solution is allowed to cool to room temperature. The solution is moved to a separatory funnel and deionized water and ethyl acetate are added. The aqueous layer is extracted with ethyl acetate. The combined organic layers are washed with water, brine, dried with MgSO4, filtered, and concentrated. The crude product is adsorbed onto a plug of silica gel and chromatographed.
As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.
Reference£º
Patent; AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION; WO2007/100880; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics