5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1 mole of 1-ethyl piperazine was dissolved in acetone and to it 3 moles of potassium carbonate was added with constant stirring. After 30 min, 1.5 mole of 1-bromo-3-chloropropane was added in drop wise manner and stirred for 12 h at RT. Later, solvent was evaporated from the reaction mixture and transferred to separating funnel having water and ethyl acetate. Organic layer was collected and evaporated to get 1-(3-chloropropyl)-4-ethylpiperazine asoily liquid. Yield 85%, IR (KBr, cm-1), 2954-2858 (Aliphatic CH str), 1350-1365 (-CN str); 1H NMR (400 MHz, Chloroform-d) delta 3.54 (t, J = 4.0 Hz, 2H), 3.16 – 3.06 (m,2H), 3.10 – 2.99 (m, 2H), 2.63 – 2.54 (m, 8H), 1.94 (tt, J =6.3, 4.0 Hz, 2H), 1.08 – 1.01 (m, 3H).
As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.
Reference£º
Article; Singh, Mahaveer; Jadhav, Hemant R.; Kumar, Amit; Letters in drug design and discovery; vol. 15; 8; (2018); p. 866 – 874;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics