With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216144-45-5,4-(4-Methylpiperazin-1-yl)benzylamine,as a common compound, the synthetic route is as follows.
[0240] Example 23: Synthesis of 2-[Benzenesulfonyl-(2-chloro-5-trifluoromethyl-phenyl)- amino]-N-[4-(4-methyl-piperazin-l-yl)-benzyl]-acetamide. [0241] To a stirred mixture of 2-(N-(2-chloro-5-(trifluoromethyl)phenyl) phenylsulfonamido)acetic acid (40.3 mg, 0.10 mmol), l-ethyl-3-(3- dimethylaminopropyl)carbodiimide HCl (24.2 mg, 0.13 mmol), and hydroxybenzotriazole (17.6 mg, 0.13 mmol) in methylene chloride (1 mL) was added a solution of (4-(4-methylpiperazin-l- yl)phenyl)methanamine (20 mg, 0.10 mmol) in N,N-dimethylformamide: methylene chloride (0.1 mL : 1 mL). The resulting solution was stirred at room temperature for a week. The mixture was concentrated, purified on silica gel eluted with a gradient of methanol: methylene chloride from 0 : 1 to 1 : 9 to provide the title product (39.2 mg). lU NMR (300 MHz, CDC13): delta 7.64-7.56 (m, 3H), 7.50-7.41 (m, 4H), 7.15-7.12 (m, 1H), 7.11-7.04 (m, 2H), 6.97 (t, = 5.3 Hz, 1H), 6.85-6.78 (m, 2H), 4.30 (d, = 5.3 Hz, 2H), 4.13 (broad s, 2H), 3.18-3.10 (m, 4H), 2.56-2.46 (m, 4H), 2.29 (s, 3H); Calculated for C27H28C1F3N403S, 580.15; observed MS (ESI) (m/z) 581.2 (M + 1)+
As the paragraph descriping shows that 216144-45-5 is playing an increasingly important role.
Reference£º
Patent; INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH; CUCONATI, Andrea; GUO, Haitao; BLOCK, Timothy M.; GUO, Ju-Tao; XU, Xiaodong; LU, Huagang; CAI, Dawei; WO2013/130703; (2013); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics