With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161357-89-7,1-(Methylsulfonyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.
Intermediate 594-{2-[5-Chloro-2-(4-methanesulfonyl-piperazin-1 -yl)-pyrimidin-4-yl1-1 -hvdroxy-ethyl)- piperidine-1 -carboxylic acid tert-butyl esterA mixture of 4-[2-(2,5-dichloro-pyrimidin-4-yl)-1 -hydroxy-ethyl]-piperidine-1 – carboxylic acid tert-butyl ester (100 mg), 1 -methanesulfonyl-piperazine hydrochloride (70 mg), potassium carbonate (100 mg), and N,N-dimethylformamide (1 mL) is stirred for 4 h at 60C. After cooling to room temperature ethyl acetate is added. The organic phase is separated, washed with water and brine, dried over MgS04, and concentrated in vacuo. The residue is chromatographed on silica gel(cyclohexane/ethyl acetate 50:50? 0: 100) to give the title compound. LC (method 7): tR = 1 .46 min; Mass spectrum (EST): m/z = 504 [M+H]+.
161357-89-7 1-(Methylsulfonyl)piperazine hydrochloride 16265612, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HIMMELSBACH, Frank; ECKHARDT, Matthias; HEINE, Niklas; LANGKOPF, Elke; NOSSE, Bernd; WO2012/80476; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics