109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.
EXAMPLE 147Preparation of 2-[4-(4-methylpiperazin-1-yl)phenyl]-4,5,6,7-tetrahydro-1 ,3- benzothiazol-7-ol Step A: 4-(4-Methylpiperazin-1-yl)benzonitrile A mixture of 4-bromobenzonitrile (1.82 g, 10 mmol), 1 -methyl piperazine (2.0 g, 10 mmol), tris(dibenzylideneacetone)dipalladium(0) (50 mg), rac-2,2′-bis(diphenylphosphino)-1,1′- binaphthyl (50 mg), and sodium te/f-butoxide (1.92 g, 20 mmol) in 20 ml. of toluene is stirred at 80 C for 18 hours and then concentrated. The residue is chromatographed over silica gel, eluting with a gradient of ethyl acetate to 20% methyl alcohol in ethyl acetate. Concentration provides 4-(4-methylpiperazin-1-yl)benzonitrile as a tan solid (1.6 g).
109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; WYETH; WO2009/120826; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics