With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 2,6-dichloro-4-cyclopr ile (synthesis described in example 4 step 2, 236 mg, 1 mmol) in N,N-dimethylformamide (10 mL) was added tert- butyl 2-methylpiperazinyl-1-carboxylate (200 mg, 1 mmol), followed by triethylamine (0.14 mL,1 mmol). The mixture was stirred at room temperature for 5 minutes, then diluted with water. The precipitated solid was collected by filtration and dried in an oven to give 4-(6- chloro-3,5-dicyano-4-cyclopropylpyridin-2-yl)-2-methylpiperazinyl-1-carboxylate (330 mg, 82%). LCMS m/z = 301.9 [M+H-Boc]+.
120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Nicholas David; BENOWITZ, Andrew B.; RUEDA BENEDE, Maria Lourdes; EVANS, Karen Anderson; FOSBENNER, David T.; KING, Bryan Wayne; LI, Mei; MILLER, William Henry; REIF, Alexander Joseph; ROMERIL, Stuart Paul; SCHMIDT, Stanley J.; WIGGALL, Kenneth; (1283 pag.)WO2017/216726; (2017); A1;,
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