With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.,109-01-3
Add 10 g (46.3 mmol) of p-nitrobenzyl bromide and 100 mL of dichloromethane to a 500 mL single-necked flask. N-methylpiperazine 4.7 g (47.0 mmol) was slowly added dropwise under ice-water bath (0-5 C) And triethylamine 7.1g (70.3 mmol) 20 mL of dichloromethane, After heating and refluxing for 1 h, The disappearance of the starting material by TLC (ethyl acetate: petroleum ether = 1:2). 150 mL of chloroform and 100 mL of a saturated sodium hydrogencarbonate solution were added to the reaction solution. Stir vigorously for 30 min at room temperature. The reaction solution was extracted with chloroform (100 mL¡Á3). Combine the organic layers, Wash once with water and saturated sodium chloride (100 mL ¡Á 1). Dried over anhydrous magnesium sulfate, filter, The solvent was evaporated under reduced pressure to give 8.5 g of pale-yellow solid, The yield is 78.1%.. The product was directly fed to the next reaction without further purification.
As the paragraph descriping shows that 109-01-3 is playing an increasingly important role.
Reference£º
Patent; China Pharmaceutical University; Wang Yue; Lu Shuai; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (26 pag.)CN109970717; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics