30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: 0.332/0.36885 g (0.001 mol) of 1-(6-bromohexyl)-1,8-naphthosultam(3a)/lactam (3b), 0.00095 mol of the corresponding arylpiperazine(4), 0.414/0.120 g (0.003 mol) K2CO3/NaOH and 0.032 g(0.0001 mol) of TBAB were triturated in a mortar. The triturated mixturewas transferred to a round bottom flask. In the case of the reactionin the presence of the solvent, 0.2 cm3 of acetonitrile, DMF or water wasadded to the reaction mixture. The reactions were carried out for 50 s ina CEM Discover microwave reactor at a 100W output power. Theprogress of the reaction was monitored by TLC (CHCl3:MeOH 9:1).After completion of the reaction, 40 cm3 of water was added to themixture and placed in the refrigerator overnight. After cooling, thecrude product was filtered off. In the absence of the required purity, thecrude product was crystallized from methanol or methanol-water. Afterobtaining a minimum of 90% purity, the ligands were dissolved inacetone, then converted to 4M HCl hydrochloride in dioxane. The reactionyields for individual ligands were calculated based on the weightof the obtained pure hydrochloride.
30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Zar?ba, Przemys?aw; Ja?kowska, Jolanta; Czekaj, Izabela; Sata?a, Grzegorz; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3396 – 3407;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics