With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.
To a suspension OF 4-METHYLPIPERAZINE-1-CARBONYL chloride hydrochloride (19.9 g 0.1 mol) and piperidone monohydrate hydrochloride (15.3 g 0.1 mol), in 200 ML of dichloromethane, dry triethylamine (45 mL, 0.33 mol) was added dropwise. The mixture was stirred for 2 hours. The organic phase was washed with brine (2 x 20 mL) and dried over sodium sulfate. After filtration, the solvent was evaporated in vacuo and the crude product was dissolved in ETOH (50 mL) and diethylether (100 mL) and treated with HCl 4N in dioxane (25 mL). After 1 hour, the precipitate was filtered and dried in oven to give 13 g (yield 50%) of the title compound. 1 H NMR (400 MHz, DMSO-D6) 8 ppm 2.40 (t, J=6. 16 Hz, 4 H) 2.81 (s, 3 H) 3.00- 3.11 (m, 2 H) 3.12-3. 23 (m, 2 H) 3.28-3. 42 (m, 2 H) 3.51 (t, J=6. 16 Hz, 4 H) 3.73 (d, J=14. 27 Hz, 2 H) 10.12 (s, 1 H), 55112-42-0
55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; PHARMACIA ITALIA S.P.A.; WO2004/104007; (2004); A1;,
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