Month: August 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

70261-82-4, To a 250 mL round bottom flask was added 7.5 g (36.6 mmol) of crude I-a ‘4-nitro-1H-pyrazole-3-carboxylic acid 6.3 g(40.1 mmol),EDC ¡¤ HCl 8.4 g (44.0 mmol)HOBt 6.0 g (44.4 mmol) and dry DMF 100 mL,Stir at room temperature for 24 h TLC detects the disappearance of the starting material (methanol: chloroform = 1:10).The reaction solution was poured into 200 mL of ice water,Precipitation of a large number of light yellow solid, standing, take the yellow solid,The crude product was recrystallized from a mixed solvent of ethyl acetate and methanol to give 11.1 g of (I-e)Yield 88.2%.

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Patent; China Pharmaceutical University; Lu Shuai; Wang Yue; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (27 pag.)CN107245073; (2017); A;,
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67455-41-8,67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Argon was passed through the suspension of bis-chloride (1) (0.419 g, 1 mmol) in dry pyridine(15 mL) at room temperature over 15 min. Amine (2.5 mmol) was added and the reaction mixture wasbubbled with argon for a further 15 min. The mixture was then stirred at room temperature for 7 days.The solid product was filtered off and washed with dry ether. The raw product was purified throughrecrystallization from ethanol.

67455-41-8 4-(Piperazin-1-yl)aniline 422925, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Zieba, Andrzej; Latocha, Ma?gorzata; Sochanik, Aleksander; Nycz, Anna; Ku?mierz, Dariusz; Molecules; vol. 21; 11; (2016);,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112984-60-8,6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

To a stuffed solution of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC.HC1, 575 mg, 3.0 mmol) in DMF at 0 C,2-picolinic acid (246 mg, 2.0 mmol) was added followed by addition of hydroxybenzotriazole(HOBt, 405 mg, 3.0 mmol) and the final reaction mixture was stuffed at 0C. After 30 mm 6-fluoro-1- methyl-4-oxo-7-(piperazin- 1 -yl)- 1 H,4H- [1,3] thiazeto[3 ,2-a] -quinoline-3 -carboxylic acid (700 mg, 2.01 mmol) and N,N-diisopropylethylamine(0.53 ml, 3 mmol) were added and reaction mixture was allowed to stir at room temperature for overnight. After completion, the reaction mixture wasevaporated, remaining mass was triturated 2-3 times and dried to obtain compound 3las an off white solid (250 mg, 28%). 1H NMR (DMSO-d6): oe 14.61 (brs, 1H, COOH), 8.62 (d, 1H, JAB = 4.5 Hz, ArH), 7.96 (t, 1H, JAB = 7.5 Hz, ArH), 7.82 (d, 1H, JAB = 13.5 Hz, ArH), 7.64 (d, 1H, JAB = 7.5 Hz, ArH), 7.52 (dd, 1H, JAB = 7.0 Hz, Jm = 5.0 Hz, ArH), 6.98 (d, 1H, JAB = 7.0 Hz, ArH), 6.36 (q, 1H, JAB = 6.0 Hz,SCHN), 3.89-3.81 (m, 2H, CH2N), 3.66-3.52 (m, 2H, C?H2N), 2.11 (d, 3H, JAB = 6.5Hz, CH3). ESI-MS (mlz): 454.92 (M+H)., 112984-60-8

As the paragraph descriping shows that 112984-60-8 is playing an increasingly important role.

Reference£º
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; GHOSH, Shamik; GHOSH, Sumana; SINHA, Mau; SADHASIVAM, Suresh; BHATTACHARYYA, Anamika; MAVUDURU, Siva Ganesh; TANDON, Nupur; KUMAR, Deepak; (149 pag.)WO2017/17631; (2017); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

Example 7 N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-6-[2-(4-methylpiperazin-1-yl)ethoxy]-1H-indole-2-carboxamide To 85 mg (0.25 MM) 6-Hydroxy-1H-indole-2-carboxylic acid [2-(cyanomethyl-carbamoyl)-cyclohexyl]-amide in 5 ml dichloromethane at 0¡ã C. was added 144 mg (1 MM) 2-(4-Methyl-piperazin-1-yl)-ethanol, 262 mg (1 MM) triphenylphosphine and 131 mg (0.75 MM) DEAD. After several hours the mixture was allowed to warm to room temperature and stir overnight.The reaction mixture was purified directly on a preparative TLC plate and eluted with 10percent methanol/dichloromethane.The product was then partitioned between 1 M HCl and ethyl acetate, the aqueous layer was neutralized and extracted with ethyl acetate, dried over magnesium sulfate and stripped to give 18.9 mg 6-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-1H-indole-2-carboxylic acid [2-(cyanomethyl-carbamoyl)-cyclohexyl]-amide. Similarly prepared were: N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-1-methyl-6-(2-morpholin-4-ylethoxy)-1H-indole-2-carboxamide using Mitsunobu coupling with 2-Morpholin-4-yl-ethanol. N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-6-(2-morpholin-4-ylethoxy)-1H-indole-2-carboxamide using Mitsunobu coupling with 2-morpholin-4-yl-ethanol., 5464-12-0

The synthetic route of 5464-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bamberg, Joe Timothy; Gabriel, Tobias; Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Palmer, Wylie Solang; Smith, David Bernard; US2004/77646; (2004); A1;,
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109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 29 2-(4-Chlorophenoxy)ethyl 3-(3-methyl-1-piperazinyl)-2-pyrazinyl Ether The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(4-chlorophenoxy)ethoxy]pyrazine* (150 mg, 0.53 mmol) and 2-methylpiperazine (256 mg, 2.56 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 143 mg (77%) of the title product. HRMS m/z calcd for C17H21ClN4O2 (M)+348.1353, found 348.1370. Anal. (C17H21ClN4O2) C, H, N. *Prepared according to the procedure described in Example 4, Step 1., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biovitrum AB; US6465467; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7 [0116] 0.61 g (1.29 mmol) of betulonic acid chloride was dissolved in 40 mL of anhydrous dichloromethane (CH2Cl2), and then 0.72 mL (5.16 mmol) of anhydrous triethylamine and 0.60 g (2.58 mmol) of 1-(4-trifluoromethylphenyl)piperazine were added thereto, and then stirred at 25 C. for 48 hours. The resulting product was washed with 10% HCl (40 mL¡Á3), further washed with pure water (40 mL¡Á3), and then a solvent layer was dried by 10 g of anhydrous Na2SO4. A dichloromethane (DCM) layer was evaporated and dried to obtain 0.85 g of light brown solids. These light brown solids were dissolved in ethanol to prepare a sample, and then this sample was fractionated by RP C18 semi-prep HPLC, and then completely evaporated and dried to obtain 0.64 g (yield: 74.9%) of 4-(4?-trifluoromethylphenylpiperazine-1-yl) amide betulonic acid. [0117] 1H NMR (600 MHz, CDCl3): [0118] A white crystalline solid, m.p. 229-230 C. IR (ATR) umax cm-1: 2944, 1704 (C?O), 1616 (CONH), 1525, 1458, 1332, 1230, 1112, 1073, 1023, 885, 830. 1H NMR (600 MHz, CDCl3): 0.93 (3H, s, Me-25), 0.96 (1H, m, H-12), 0.97 (3H, s, Me-27), 0.98 (3H, s, Me-26), 1.02 (3H, s, Me-24), 1.06 (3H, s, Me-23), 1.19 (1H, m, H-15), 1.30-1.52 (12H, m, H-1, 5, 6, 6, 7, 7, 9, 11, 11, 15, 16, 21), 1.59 (2H, m, H-12, 18), 1.69 (3H, s, Me-30), 1.75 (1H, m, H-22), 1.89 (2H, m, H-1, 21), 2.01 (1H, m, H-22), 2.16 (1H, m, H-16), 2.39 (1H, m, H-2), 2.49 (1H, m, H-2), 2.92 (1H, m, H-13), 3.00 (1H, dt, J1=11.4 Hz, J2=4.2 Hz, H-19), 3.41 (4H, m, H-3?, 3?, 5?, 5?), 3.78 (4H, m, H-2?, 2?, 6?, 6?), 4.74 and 4.60 (2H, both br. s, H-29), 6.94 (2H, d, J=8.4 Hz, H-2?, 6?), 7.51 (2H, d, J=8.4 Hz, H-3?, 5?). [0119] C41H59N2O2F3, 4-(4?-trifluoromethylphenylpiperazine-1-yl) amide betulonic acid 7, 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KOREA INSTITUTE OF ENERGY RESEARCH; Chue, Kuck-Tack; Kim, Tae-Hwan; Ten, Leonid; US2014/243527; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

381242-61-1, 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred mixture of 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate (1) (1.65 g, 0.005 mol), C2H5OH (30 mL) and N(C2H5)3 (3 mL), 1-[4-nitro-2-(trifluoromethyl)phenyl]piperazine (2) (1.65 g, 0.006 mol) was added and heated at 70-80 C for 5 h. The reaction was monitored by TLC. After filtration, the filtrate was evaporated under reduced pressure. Water (30 mL) was added to the residue, which was then extracted with ethyl acetate (80 mL ¡Á 3). The extract was washed with saturated NaCl solution (20 mL ¡Á 3), dried over anhydrous Na2SO4 and evaporated. The residue was crystallized from C2H5OH to afford a white solid 3 1.92 g, in 75% yield: m.p. 115-117 C. 1H NMR (DMSO-d6): 6.80-8.48 (6H, m, Ar-H), 7.81, 8.13 (2H, ss, triazole-H), 4.51-4.60 (2H, dd, J = 15 Hz, triazole-CH2-), 2.50-3.01 (8H, m, piperazine-H), 2.73-3.17 (2H, dd, J = 15 Hz, CH2-piperazine-), 5.10 (1H, s, OH). IR (KBr): 3200, 2940, 2893, 1605, 1514, 1338, 1257, 1136, 918 cm-1. LC-MS, m/z Calcd. for C22H21F5N6O3, 512.2, found [M + H]+ 513.3., 381242-61-1

As the paragraph descriping shows that 381242-61-1 is playing an increasingly important role.

Reference£º
Article; Chai, Xiaoyun; Zhang, Jun; Cao, Yongbing; Zou, Yan; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Sun, Qingyan; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 3167 – 3176;,
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692058-21-2, 1-Boc-4-(2,2,2-trifluoroethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,692058-21-2

The 4 – (2, 2, 2- three fluorine ethyl ) piperazine-1-carboxylic acid T-butyl ester (1.2g) into the reaction bottle in, addition of about 8mL2.08MHCl the dioxane solution, stirring the mixture at room temperature for overnight, filtering, the mixed solution of ethyl ether and EA washing the solid, the white solid obtained, spare to the next step directly.

As the paragraph descriping shows that 692058-21-2 is playing an increasingly important role.

Reference£º
Patent; Institute Of Materia Medica Chinese Academy Of Medical Sciences; Xu, Bailing; Chen, Xiaoguang; Yao, Haiping; Ji, Ming; Jin, Jing; Zhou, Jie; Wang, Ke; Zhao, Dalong; (55 pag.)CN105461697; (2016); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.,109-01-3

Add 10 g (46.3 mmol) of p-nitrobenzyl bromide and 100 mL of dichloromethane to a 500 mL single-necked flask. N-methylpiperazine 4.7 g (47.0 mmol) was slowly added dropwise under ice-water bath (0-5 C) And triethylamine 7.1g (70.3 mmol) 20 mL of dichloromethane, After heating and refluxing for 1 h, The disappearance of the starting material by TLC (ethyl acetate: petroleum ether = 1:2). 150 mL of chloroform and 100 mL of a saturated sodium hydrogencarbonate solution were added to the reaction solution. Stir vigorously for 30 min at room temperature. The reaction solution was extracted with chloroform (100 mL¡Á3). Combine the organic layers, Wash once with water and saturated sodium chloride (100 mL ¡Á 1). Dried over anhydrous magnesium sulfate, filter, The solvent was evaporated under reduced pressure to give 8.5 g of pale-yellow solid, The yield is 78.1%.. The product was directly fed to the next reaction without further purification.

As the paragraph descriping shows that 109-01-3 is playing an increasingly important role.

Reference£º
Patent; China Pharmaceutical University; Wang Yue; Lu Shuai; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (26 pag.)CN109970717; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.171504-98-6,Methyl 1,4-Bis(Boc)-2-piperazinecarboxylate,as a common compound, the synthetic route is as follows.

Step 2: To a solution of Compound All (13.4 g, 38.9 mmol) in 200 mL of anhydrous THF was added freshly prepared LDA (2M in THF, 38 mL) at -78 C. The reaction mixture was stirred for 30 minutes at -78 C. and then warmed to room temperature for 30 minutes. The mixture was cooled down to -78 C. and a solution of allyl bromide (6.7 mL, 77.9 mmol) in 10 mL of THF was added. After the mixture was warmed to room temperature and stirred overnight, the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography to afford Compound AI (yield 13.6 g, 91%)., 171504-98-6

As the paragraph descriping shows that 171504-98-6 is playing an increasingly important role.

Reference£º
Patent; HOFFMANN-LA ROCHE INC.; Guo, Lei; Hu, Taishan; Kou, Buyu; Lin, Xianfeng; Shen, Hong; Shi, Houguang; Yan, Shixiang; Zhang, Weixing; Zhang, Zhisen; Zhou, Mingwei; Zhu, Wei; US2015/252057; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics