5747-48-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5747-48-8,11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine,as a common compound, the synthetic route is as follows.
A mixture of PDBTZ (1 mmol), acetaldehyde (1 mmol), and a catalytic amount of p- toluenesulfonic acid in dry benzene is refluxed for two hours using a Dean-Stark trap to separate water. The reaction mixture is evaporated and the residue purified by flash chromatography to provide the title compound.
As the paragraph descriping shows that 5747-48-8 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; WO2008/79847; (2008); A1;,
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