694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred reaction mixture of XXVII (0.31 g, 0.99 mmol), V (0.27 g, 1 mmol), HATU (0.76 g, 2mmol) & DIPEA (0.646 g, 5 mmol) in DMF (5 mL) at RT for 16 h. Reaction mixture was diluted withwater and extracted with ethyl acetate (50 mL X 3), organic layer was washed with saturated brine solution(50 mL X 3), combined organic layer dried over anhydrous sodium sulphate, concentrated under vacuumto obtain crude which was purified by column chromatography using 100-200 silica gel (Eluent system-1% to 10 % MeOH: DCM) to obtain desired product XXVIII (0.200 g, 35%).LCMS: 575 [M+1]+
694499-26-8, As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.
Reference£º
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics