13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of lie (9.54 g, 74.4 mmol) and K2C03 (1 .7 g, 85.1 mmol) in DMF (60 mL) 1 -fluoro- 2-nitrobenzene lb (10.0 g, 70.9 mmol) was added at 25qC. Obtained reaction mixture was stirred at 50 C for 17 h and then water (200 mL) was added. The product was extracted to EtOAc (3 x 150 mL), combined organic layers were washed with water (3 x 100 mL) and brine (2 x 100 mL), dried over MgS04, and solvent was evaporated to afford the title compound Illc as orange oil which solidified upon standing. Orange crystals (17.4 g, 99% yield): H NMR (CDCI3, 500 MHz) 5 2.13 (s, 3H), 3.05 (m, 4H), 3.62 (m, 2H), 3.77 (m, 2H), 7.10-7.17 (m, 2H), 7.51 (m, 1 H), 7.80 (m, 1 H); MS (ESI) mlz. 250 [MH]+., 13889-98-0
13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; LEK PHARMACEUTICALS D.D.; ZUPANCIC, Borut; WO2015/107057; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics