With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53788-49-1,tert-Butyl 4-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
53788-49-1, Indole-2-carboxylic acid (5.2 g) in THF (200 mL) was treated with [CARBONYIDIIMIDAZOLE] (4.8 g) and stirred at ambient temperature for 10 min whereupon [4-METHYL-PIPERAZINE-1-CARBOXYLIC] acid tert-butyl ester (5.0 g) was added. The mixture was stirred at ambient temperature for 72 h and the solvent removed under reduced pressure. The residue was dissolved in ethyl acetate and washed with saturated sodium bicarbonate solution. The organic portion was separated, dried over sodium sulfate and filtered, and solvent was evaporated to afford a solid. Recrystallization from hot ethanol afforded [4- (1 H-] lndole-2-carbonyl)-piperazine-1-carboxylic acid ter-butyl ester (4. 2 g).
As the paragraph descriping shows that 53788-49-1 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2004/22061; (2004); A1;,
Piperazine – Wikipedia
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