With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
To a solution of 1-piperazin-l- ylethanone (2.00 g, 15.6 mmol) and K2CO3 (4.31 g, 31.2 mmol) in CH3CN (50.0 mL) was added 3-bromopropan-l-ol (3.25 g, 23.4 mmol). The mixture was stirred at 80 C for 5 hours. The solid was filtered and the filtrate was evaporated to give l-[4-(3-hydroxypropyl)piperazin- l-yl]ethanone (2.00 g, 10.7 mmol, 68.8 % yield) as a colorless oil., 13889-98-0
The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
Piperazine – Wikipedia
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