259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
j00268j 8-Cyclopropyl-6-(4-fluorophenyl)imidazo[ 1 ,2-b]pyridazine-2-carboxylic acid (80 mg, 0.27 mmol) was dissolved in DMF (3.4 mL) and DIPEA (121.7 mg, 164 tL, 0.94 mmol) followed by tert-butyl 3,3-dimethylpiperazine-1-carboxylate (69.20 mg, 0.3229 mmol) were successively added at r. t. After 2 mi HATU (153.5 mg, 0.40 mmol) was added and the reaction mixture was stirred at r.t. ON. Water was added and the reaction mixture and the mixture was extracted with EtOAc. The resulting organic phase was washed twice with a 1:1 mixture of water and brine, dried over anhydrous Mg504, filtered and evaporated under reduced pressure. The resulting crude product was used as such in the next reaction. LC-MS:mlz = 494.26 (M+Hj.
259808-67-8, 259808-67-8 1-Boc-3,3-Dimethylpiperazine 22710387, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; FARMER, Luc J.; FOURNIER, Pierre-Andre; LESSARD, Stephanie; LIU, Bingcan; ST-ONGE, Miguel; STURINO, Claudio; SZYCHOWSKI, Janek; YANNOPOULOS, Constantin; WO2015/48245; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics