With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.
76003-29-7, In a 500 mL three-necked flask, 12.70 g (63.0 mmol, 1.0 eq.) of Compound 1 was dissolved in 280 mL of dimethylformamide and cooled to 0 C in an ice bath;1.73 g (73.0 mmol, 1.15 equivalents) of sodium hydride were added and stirred under ice cooling for 1 hour.Then 6.60 mL (69.0 mmol, 1.10 equivalents) of methyl bromoacetate was added via syringe.After further stirring for 20 minutes under ice cooling, the reaction solution was warmed to room temperature. After 18 hours, 10 mL of methanol, 10 mL of deionized water and 180 mL of a saturated sodium chloride solution were added to the reaction solution.The aqueous phase the organic phase was extracted once with 250mL to 140mL extracted three times with ether, and the combined dried over magnesium sulfate, and the solvent was evaporated under reduced pressure.Subsequently, it was removed under reduced pressure at a water temperature of 55 C in 2 hours.Residual dimethylformamide. Obtaining 13.4 g of an orange liquid, purified by flash chromatography using petroleum ether/ethyl acetate 4:1? petroleum ether/ethyl acetate 2:1 as eluent.Got a white solid,Yield: 14.16g (82%, 52.0mmol),White solid,
76003-29-7 1-Boc-3-Oxopiperazine 3157178, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; Shaoxing University; Hu Chunqi; Li Xin; Shi Yaru; Du Wenting; Tong Jie; Su Wanting; Xia Weiqi; (21 pag.)CN108610333; (2018); A;,
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