122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To n-butanol (2 mL) was added compound 4A-3 (30 mg, 0.135 mmol) and compound 5A-3 (48 mg, 0.135mmol), and then p-toluenesulfonic acid (23 mg, 0.132 mmol) was added under stirring. The mixture was heated to 100C and stirred for 5 hours. After TLC indicated the reaction was completed, the reaction mixture was concentrated under reduced pressure to give a crude product, which was further purified and isolated by column chromatography to obtain an off-white solid product, compound I-2 (25 mg, yield 34.3%). 1H NMR (400 MHz, cd3od) delta 8.11 (s, 1H), 8.05 (s, 1H), 7.81 (d, J=5.5 Hz, 1H), 7.57 (d, J=8.6 Hz, 1H), 6.68 (d, J=2.3 Hz, 1H), 6.57 (dd, J=8.7, 2.4 Hz, 1H), 3.83 (s, 3H), 3.42-3.34 (m, 1H), 3.29 (s, 4H), 2.89 (s, 4H), 2.55 (s, 3H), 1.30 (d, J=6.7 Hz, 6H). LCMS: t=0.690 min, 537.2 (M), 538.2 (M+1).
122833-04-9, The synthetic route of 122833-04-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Humanwell Healthcare (Group) Co., Ltd.; WANG, Xuehai; XU, Yong; SHENG, Xijun; ZHANG, Xiaolin; XIA, Hangui; YANG, Zhongwen; YUE, Yang; HUANG, Lu; XIAO, Qiang; (80 pag.)EP3372594; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics