314741-39-4, (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A 50 L glass-lined reactor was charged with the above solution of ethyl 3-isocyanato-2,2- dimethyl-propanoate (Example 1) in DCM . To the solution, cooled to 5-10 C, was added 01-tert-butyl 03-methyl (3S)-piperazine-1,3-dicarboxylate (2.64 kg, 10.81 mol, Compound IV) in portions below 10 C. The reaction mixture was stirred for 2 hours at 25 C. The solvent was removed at 40 C/0.O7MPa to give the crude Example 2 (4.9 kg, purity: 94.98 %) which was used directly for the next step. Analytically pure Example 2 was obtained as an oil by flash chromatography. ?H NMR (400 MHz, CDC13) (55.45-5.48 (m, 1H), 4.85 (s, br, 1H), 4.54 (d, J=13.6, 1H), 4.12 (q, J= 7.6, 2H), 3.69 (s, 3H), 3.30-3.38 (m, 4H), 3.06-3.09 (m, 1H), 2.87 (s, br,1H), 1.41 (s, 9H), 1.24 (t, J= 7.6, 3H), 1.16 (s, 6H); MS mle = 416.1 [M+H] ., 314741-39-4
The synthetic route of 314741-39-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHEN, Junli; (58 pag.)WO2017/140750; (2017); A1;,
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