197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 1 te/t-Butyl-4-(4-(6-bromo-7-(4-(cyclobutylmethyl)piperazin-1-yl)-3H-imidazo[4,5- b]pyridin-2-yl)phenyl)piperazine-1-carboxylateTo a mixture of 5-bromo-4-(4-(cyclobutylmethyl)piperazin-1-yl)-3-nitropyridin-2-amine (prepared as described in example 149 of PCT/GB2006/004854; 0.12 g, 0.32 mmol, 1eq) in EtOH (5.6 ml_) and DMF (0.74 ml_), tert-butyl 4-(4-formylphenyl)piperazine-1- carboxylate (0.102 g, 0.35 mmol, 1.1 eq) was added followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.96 mL, 0.96 mmol). The reaction mixture was heated at 85 0C for 24 h, then allowed to cool to room temperature and diluted with DCM and a few drops of aqueous NH3 until complete dissolution was observed. This solution was deposited on two preparative silica TLC plates and eluted with DCM/MeOH (v/v 94:6) to give the title compound as an off-white solid (0.043 g, 22%); 1H-NMR (500Mz, DMSO-c/6): delta 1.43 (s, 9H, C(CH3)3), 1.60-1.75 (m, 2H), 1.76- 1.94 (m, 2H), 2.00-2.11 (m, 2H), 2.35-2.48 (brs, 2H), 2.50-2.65 (m, 4H), 3.43-3.52 (m, 4H), 3.55-3.69 (brs, 4H), 7.07 (d, J = 9.0 Hz, 2H, ArH, C6H4), 8.04 (d, J = 8.5 Hz, 2H, ArH, C6H4), 8.17 (s, 1H, imidazo[4,5-b]pyridine 5-H)1 13.22 (br s, 1 H1 imidazo[4,5-b]pyridine N-H), two signals (one from the cyclobutyl ring and that from one of the two piperazinyl ring were hidden under solvents’ signals; LC (Method B) – MS (ESI, m/z) 3.86 min – 610/612 [(M+H)+, Br isotopic pattern]. ESI-HRMS: Found: 610.2504, calculated for C30H4iN7O2Br (M+H)+: 610.2499., 197638-83-8
197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics