With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
59702-07-7, To the mixture of 450 mg 1-methylpiperazin-2-one (3.00 mmol) and 1.00 g K2C03 (7.24 mmol) in 5 mL TI-IF I mL 2-bromoethanol (14. Immol) was added and the mixture was stirred at 65¡ãC for 16h. The mixture was cooled to room temperature, filtered andconcentrated under reduced pressure. The residue was purified via flash chromatography using DCM and MeOH to give 4-(2-hydroxyethyl)-1-methyl-piperazin-2-one.MS: (M+H) 159.4.
As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.
Reference£º
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; SZLAVIK, Zoltan; CSEKEI, Marton; PACZAL, Attila; SZABO, Zoltan; SIPOS, Szabolcs; RADICS, Gabor; PROSZENYAK, Agnes; BALINT, Balazs; BRUNO, Alain; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; CHEN, I-Jen; PERRON-SIERRA, Francoise; WO2015/97123; (2015); A1;,
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