Simple exploration of 780753-89-1

780753-89-1, 1-(4-Fluorophenyl)piperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 12^{^-Chloro-S-ttrifluoromethylJphenylJcarbony^-i^-fluorophenyl)^- piperazinone (E12); A solution of 1-(4-fluorophenyl)-2-piperazinone (100 mg, 0.52 mmol, prepared as described below), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (158 mg, 0.82 mmol), and lambda/,lambda/-dimethyl-4-pyridinamine (252 mg, 2.06 mmol) in dichloromethane (4 ml) was stirred at room temperature under argon. 2-Chloro-3- (trifluoromethyl)benzoic acid (116 mg, 0.52 mmol) was added portionwise and the mixture was left overnight. Dichloromethane and aqueous 3N citric acid were then added and the mixture was extracted into dichloromethane (x2). The dichloromethane layers were combined and washed sequentially with water (x1 ), saturated aqueous sodium hydrogen carbonate (x1 ), water (x1 ), and brine (x1 ), and then dried over magnesium sulphate. The solvent was evaporated in vacuo and the crude product was purified by flash-silica gel chromatography, eluting with 30-70percent ethyl acetate in isohexane, to give 4-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-1- (4-fluorophenyl)-2-piperazinone (101 mg) as a white solid. LC/MS [M+H]+ = 401 , retention time = 2.70 minutes.

780753-89-1, The synthetic route of 780753-89-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2009/53459; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics