120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of (S) -5- (1- ( (tert-butoxycarbonyl)amino) ethyl) -2- (3- (cyclopropylmethoxy) -4- (difluoromethoxy) phenyl)oxazole-4-carboxylic acid (250 mg, 0.53 mmol) , tert-butyl 2-methylpiperazine-1-carboxylate (130mg, 0.64 mmol) , EDCI (155 mg, 0.80 mmol) and HOAT (182 mg, 1.33 mmol) in DCM(15 mL) was stirred at 0 , and DIPEA (0.37 mL, 2.14 mmol) was added dropwise.After the addition, the mixture was stirred at rt for 5 h and washed with water(10 mL ¡Á 2) . The organic layer was dried over anhydrous Na2SO4and concentrated. The residue was purified by silica gel chromatography elutedwith Petroleum ether/EtOAc (v/v) 2/1 to give the title compound as colorlessthick oil (215 mg, 60) . 1H NMR (400 MHz, CDCl3): delta ppm 7.58 (d, J 8.0 Hz, 1H) , 7.54 (s, 1H) , 7.24 (d, J 8.4 Hz, 1H) ,6.69 (t, JF-H 75.0 Hz, 1H) , 5.27-5.20 (m, 1H) , 4.64-4.43 (m, 3H), 3.96 (d, J 6.7 Hz, 2H) , 3.92-3.89 (m, 1H) , 3.25-3.02 (m, 3H) , 1.54 (d, J 7.0 Hz, 3H) , 1.48 (s, 9H) , 1.41 (s, 9H) , 1.35-1.32 (m, 1H) , 1.22-1.14 (m,3H) , 0.71-0.66 (m, 2H) , 0.41-0.40 (m, 2H) and MS-ESI: m/z 651.3 [M+H] +.
120737-78-2, The synthetic route of 120737-78-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
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