438631-77-7, (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
DIPEA (1.79 ml, 10.25 mmol) was added to a solution of 3-bromo-8-chloro-2,4-dimethyl-7-nitro-1,5-naphthyridine (2.95 g, 9.32 mmol) and 1-tert-butyl 3-methyl (3R)-piperazine-1,3-dicarboxylate (2.39 g, 9.79 mmol) in THF (40 ml). The resultant brown solution was heated at 65 C. for 24 h. The reaction mixture was concentrated in vacuo, the residue re-dissolved in ethyl acetate and washed with water (*2) and brine. The aqueous layer was back extracted with ethyl acetate and the combined organics dried (phase separator) and concentrated in vacuo to afford crude material as a brown foam. This was purified by flash silica chromatography (0 to 100% ethyl acetate in heptane) to afford 1-tert-butyl 3-methyl (3R)-4-(7-bromo-6,8-dimethyl-3-nitro-1,5-naphthyridin-4-yl)piperazine-1,3-dicarboxylate (4.13 g, 85%) as a yellow solid; 1H NMR (400 MHz, DMSO, 30 C.) 1.42 (9H, s), 2.74 (3H, s), 2.82 (3H, s), 3.09-3.15 (1H, m), 3.24 (1H, s), 3.55 (1H, d), 3.67 (3H, s), 3.73-3.84 (1H, m), 3.88 (1H, s), 4.37 (1H, d), 5.59 (1H, s), 9.04 (1H, s); m/z: ES+ [M+H]+ 523.9.
438631-77-7, 438631-77-7 (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 6558432, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics