With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
5-(bromoacetyl)-2-fluorobenzonitrile (590 mg, 2.44 mmol) and (S)-4-N-BOC-2-hydroxymethyl-piperazine (527 mg,2.44 mmol) were dissolved in THF (40 mL) at 0C then TEA (247 mg, 2.44 mmol) was added. The reaction mixturewas stirred at RT for 16 h, then poured into water and extracted with ethyl acetate. The organic layer was dried overNa2SO4, filtered, and evaporated to dryness. The crude product was purified by MPLC through an 80g Redi-sepcolumn using 0-100% EtOAc/hexane to yield the title compound.
314741-40-7, As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.
Reference£º
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics