With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
The starting material was prepared as follows: A suspension of 1-acetylpiperazine (3.85 g, 0.03 mol) and 3-bromopropan-1-ol (4 ml) containing potassium carbonate (8.3 g, 60 mmol) in acetonitrile (30 ml) was stirred at 80 C. for 5 hours. The solid was filtered and the filtrate was evaporated. The residue was purified by column chromatography eluding with ethanol/methylene chloride (1/9 followed by 3/7) to give 3-(4-acetylpiperazin-1-yl)propan-1-ol (3.15 g, 56%). 1H NMR Spectrum: (CDCl3) 1.75 (m, 2H), 2.05 (s, 3H), 2.4-2.5 (m, 4H), 2.6 (t, 2H), 3.45 (t, 2H), 3.6 (m, 2H), 3.8 (t, 2H), 4.6 (br s, 1H) MS: 187.4 (M+H)+, 13889-98-0
As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.
Reference£º
Patent; Hennequin, Laurent Francois Andre; US2003/212055; (2003); A1;,
Piperazine – Wikipedia
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