1235865-77-6, 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2 – ((1H-pyrrolo [2,3-b] pyridin-5-yl) oxy) -4- (4 – ((4′-chloro-5,5-dimethyl- (0.191 g, 0.335 mmol, 1 eq) (see Step 14 of Example 1), and the title compound was prepared from 6-tetrahydro- [1,1′-biphenyl]4- (2- (4-oxaspiro [2.4] heptan-6-yloxy) ethoxy) -3-nitrobenzenesulfonamide (0.120 g, 0.335 mmol, 1 eq)EDCI (0.077 g, 0.402 mmol, 1.2 eq), DMAP (0.123 g, 1.00 mmol, 3 eq) and 10 mL DCM were placed in a one-necked flask at 0 C for half an hour and then reacted at room temperature. TLC was complete. Quenching reaction, liquid separation, organic phase drying, spin drying, column chromatography EA: DCM = 1: 1 to get the product 0.150g, yield 49%.
1235865-77-6, As the paragraph descriping shows that 1235865-77-6 is playing an increasingly important role.
Reference£º
Patent; Sunshine Lake Pharma Co.,Ltd.; Kou, Yuhui; Hu, Bolin; Jiang, Haigang; Ye, Jiuyong; Liu, Zhiqiang; Xie, Hongming; Zhang, Yingjun; (42 pag.)CN106565706; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics