170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5-Bromo-iV -[4-chloro-3-methoxyphenyl]-iV2-(4-[4-(l,l- dimethylethoxy)carbonylpiperazin-l-yl]phenyl)pyrimidine-2,4-diamine (MA2-010): This was obtained by stirring MA2-004 (0.698 g) and 4-(4-tert-butoxycarbonylpiperazino)aniline (0.555 g) in isopropanol (4 mL) at 85 C (oil bath) for 24 h. The reaction mixture was allowed to cool to room temperature and diluted with water (50 mL) which led to the precipitation of product. The crude product was filtered and washed with water (4 x 10 mL) and hexane (4 x 10 mL) to provide MA2-010 as a grey solid (0.960 g, 81%). Mp: 194-195 C. NMR (400 MHz, DMSO-i acquired at 70 C): delta 8.92 (s, IH, disappeared on D2O shake), 8.41 (s, IH, disappeared on D2O shake), 8.17 (s, IH), 7.43-7.37(m, 3H), 7.34-7.28 (m, 2H), 6.82 (d, J= 9.0 Hz, 2H), 3.75 (s, 3H), 3.50-3.45 (m, 4H), 3.06-3.00 (m, 4H), 1.44 (s, 9H). HPLC-MS (ESI+): m/z 591.2 [100%, (M81Br35Cl+H)+ and (M79Br37 +], 589.2 [70%, (M79B35C1 +H)+].
170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; (257 pag.)WO2016/22460; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics