70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,70261-82-4
[0172] A suspension of intermediate 31 (50 mg, 0.18 mmol), 4-(4-methyl-piperazin-l- ylmethyl)-phenylamine (50 mg, 0.24 mmol), Pd2(dba)3 (10 mg, 0.011 mmol), Xantphos (13 mg, 0.022 mmol) and cesium carbonate (0.12 g, 0.37 mmol) in dioxane/DMF (3/1, 4 mL) was sealed in a microwave reaction tube and irradiated with microwave at 160 C for 15 min. After cooling to room temperature, the cap was removed and the resulting mixture filtered and the filtered solid washed with DCM. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (DCM to 10% MeOH/DCM)to afford the title compound (35 mg, 44%) as an off white solid.[0173] 1R NMR (500 MHz, DMSOd6): 5 2.11 (s, 3H), 2.15 (s, 3H), 2.20-2.45 (m, 8H), 3.35 (s, 2H), 3.75 (s, 3H), 7.07 (d, J= 8.5 Hz, 2H), 7.28 (d, J= 8.5 Hz, IH), 7.44 (dd, J= 8.7, 2.3 Hz, IH), 7.47 (d, J= 2.3 Hz, IH), 7.57 (d, J= 8.5 Hz, 2H), 7.91 (s, IH), 8.36 (s, IH), 8.98 (s, IH). MS (ES+): m/z 453 (M+H)+.
The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
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