Analyzing the synthesis route of 674792-05-3

As the paragraph descriping shows that 674792-05-3 is playing an increasingly important role.

674792-05-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.674792-05-3,(S)-1-Boc-2-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

1-Propanephosphonic acid cyclic anhydride (1.752mmol, 1.043ml_, 1115mg) was added to a solution of (S)-tert-butyl 2-isopropylpiperazine-1-carboxylate (0.876mmol, 200mg), 4-amino-3-fluorobenzoic acid (0.876mmol, 136mg) and triethylamine (1.752mmol, 0.244 mL, 177mg) in dichloromethane and stirred at room temperature for 2 hours. After this time, ethyl acetate (10OmL) was then added to the reaction. The organic mixture was washed with saturated sodium hydrogen carbonate, water, dried over sodium sulphate and concentrated under vacuum. The residue was then dissolved in dichloromethane (5ml_) and trifluoroacetic acid (17.52mmol, 1997mg) added. The resultant solution was allowed to stand at room temperature overnight. The reaction was concentrated under vacuum and purified by strong cation exchange chromatography to give the title compound (200mg) as a clear oil. MS (ESI) m/z 266.3 [M+H]+

As the paragraph descriping shows that 674792-05-3 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; WO2009/24550; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics