694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,694499-26-8
A solution of 740 mg (2.71 mMol) of 4- (4-METHYL-PIPERAZIN-1-YLMETHYL)-3- trifluoromethyl] benzenamine in 12.5 ml CH2CI2 and 2.5 ML pyridine is cooled in an ice-bath under N2-atmosphere. Then a solution of 375 PL (2.85 MMOL) of 2-nitrobenzoyl chloride (Fluka, Buchs, Switzerland) in 12.5 ml CH2CI2 is added dropwise. After 30 min, the resulting mixture is diluted with EtOAc and 0.5 N HCI, the aqueous layer separated off and extracted with EtOAc. The organic phases are washed 3 times with 0.5 N HCI and then discarded. The combined aqueous phases are turned basic by the addition of saturated NA2CO3 solution and extracted with 3 portions of EtOAc. The organic phases are washed with brine, dried (NA2SO4) and CONCENTRATED IN VACUUO. COLUMN chromatography (SiO2 ; ETOAC X EtOAc/EtOH (+ 1 % ET3N) 97: 3) gives the title compound ; MS: [M+1] + = 423.
As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.
Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/52884; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics