78551-60-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78551-60-7,tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To EtMgBr (344 mL) in THF cooled to -78C was added Ti(O1Pr)4 (39 g, 137.93 mmol), followed by commercially available 4-benzyl-3-oxo-piperazine-l-carboxylic acid tert- butyl ester (40 g, 137.93 mmol) and the resultant reaction mixture was heated to reflux for 1 h. After cooling the reaction mixture to 5C, another portion of EtMgBr (344 ml) and Ti(O1Pr)4 (39 g, 137.93 mmol) was added. The mixture was stirred for 16 h at RT. The reaction mixture was quenched with NH4CI solution and stirred for 15 min and filtered through a celite bed and washed with EtOAc. The aqueous layer was again extracted with EtOAc (3 x). The combined EtOAc layers were washed with water and dried over Na2SO4 and concentrated under reduced pressure. Purification by column chromatography to afforded the title compound as a solid (24 g, 58%). 1H NMR (300 MHz, DMSO) delta = 7.20 (m, 5H), 3.80 (s, 2H), 3.40 (m, 2H), 3.22 (m, 2H), 2.63 (m, 2H), 1.38 (s, 9H), 0.58 (br, 4H)
The synthetic route of 78551-60-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LEO PHARMA A/S; NIELSEN, Simon Feldbaek; GREVE, Daniel, Rodriguez; RYTTERSGAARD, Carsten; GRUE-S?RENSEN, Gunnar; OTTOSEN, Erik, Rytter; POULSEN, Tina, Dahlerup; SCHOU, S¡ãren, Christian; MURRAY, Anthony; WO2011/3418; (2011); A1;,
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