120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 4,6-dimethyl-2-(o-tolyl)pyrimidine-5-carboxylic acid (26) (40 mg, 0.17 mmol), tert-butyl 2-methylpiperazine-1-carboxylate45 (50 mg, 0.25 mmol), HOBt(25 mg, 0.18 mmol), EDCI (28 mg, 0.18 mmol) and DIPEA (0.06 mL,0.33 mmol) in DCM (10 mL) was stirred at room temperature for18 h. The solution was then concentrated in vacuo before the residue was purified via silica gel chromatography (1:1 ethyl acetate/hexane) to afford compound 28, a clear oil (45 mg, 65%), as a mixture of conformers. Rf 0.44 (1:1 ethyl acetate/hexane). 1H NMR(CDCl3) d: 7.77e7.74 (m, 1H), 7.34e7.25 (m, 3H), 4.65 (m, 0.5H), 4.51 (m, 0.5H), 4.47 (m, 0.5H), 4.27 (m, 0.5H), 4.02 (m, 0.5H), 3.90 (m,0.5H), 3.40e3.32 (m, 1H), 3.21e2.95 (m, 3H), 2.59 (s, 1.5H), 2.57 (s,1.5H), 2.52 (s, 3H), 2.45 (s, 1.5H), 2.43 (s, 1.5H), 1.46 (s, 9H), 1.27 (d,J6.8 Hz, 1.5H), 1.12 (d, J6.8 Hz, 1.5H). 13C NMR (CDCl3) d: 168.1,167.8, 166.8, 166.8, 163.4, 162.8, 162.4, 154.41, 154.37, 137.9, 137.8,137.4, 137.3, 131.4, 131.43, 131.41, 130.38, 130.36, 129.64, 129.60,126.0, 125.8, 125.4, 80.6, 50.3, 46.9, 46.3, 46.2, 45.5, 41.5, 38.8, 38.0,28.5, 22.55, 22.50, 22.20, 22.15, 21.10, 21.08, 15.6, 15.5. To a solution of tert-butyl 4-(4,6-dimethyl-2-(o-tolyl)pyrimidine-5-carbonyl)-2-methylpiperazine-1-carboxylate (28) (45 mg,0.11 mmol) in DCM (3 mL) was added 10 drops of TFA and allowed to stir at room temperature for 18 h. The volatiles were evaporated to afford the product, a colourless oil (35 mg, quant.) as a mixture of conformers., 120737-78-2
120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Lim, Zelong; Duggan, Peter J.; Wan, Soo San; Lessene, Guillaume; Meyer, Adam G.; Tuck, Kellie L.; Tetrahedron; vol. 72; 9; (2016); p. 1151 – 1160;,
Piperazine – Wikipedia
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