With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
31166-44-6, Dissolve compound 13 (500 g, 2.27 mol) in concentrated hydrochloric acid (1250 mL) And water (1250 mL),Then add sodium nitrite (469.89 g, 6.81 mol) dropwise at 25-30C within one hour.Dissolved in water (1000 mL) solution.The reaction was stirred at 25 C for 1 hour.TLC (petroleum ether: ethyl acetate = 1:1) showed complete reaction. The reaction was poured into ethyl acetate (2 L), the layers were separated and the aqueous layer was extracted with ethyl acetate (1 L x 2). The organic layers were combined, washed with 1 L of saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to give the title compound 14 (yellow oil, 560 g, yield: 94.58%). It was used in the next step without purification.
31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; CHANGZHOU YINSHENG PHARMACEUTICAL CO., LTD.; FU, ZHIFEI; ZHANG, YANG; CHEN, SHUHUI; (29 pag.)TW2017/34011; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics