13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate (c) (1.82 g, 4.8 mmol), palladium acetate (52 mg, 0.24 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (240 mg, 0.48 mmol), cesium carbonate (2.32 g, 7.2 mmol) is dissolved in dioxane (15 ml), add 1-acetylpiperazine (0.92 g, 7.2 mmol), nitrogen protection, 100 C reflux stirring 6 hr, the reaction liquor is brown clear liquid. To the reaction solution to room temperature, add 15 ml water, ethyl acetate (10 ml ¡Á 3) extraction, the combined organic phase, dried with anhydrous sodium sulfate, filtered concentrated by reduced pressure distillation, column chromatography (PE: EtOAc=1:1), to obtain white solid 1.5 g, yield 75%.
13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Fudan University; Fu Wei; Sun Nannan; (18 pag.)CN108503584; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics