With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-70-5,(S)-tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Description 149(S)-tert-butyl 4-(5-fluoro-2-methyl-3-nitrobenzyl)-2-methylpiperazine-1-carboxylate (D149)To a solution of 5-fluoro-2-methyl-3 -nitrobenrzaldehyde (D142, 10 g) and (S)-tert-butyl 2-methylpiperazine-l-carboxylate (12.03 g) in DCM (120 mL) was added drops of acetic acid (3.28 g) and the mixture was stirred at RT for 1 hour. Sodium triacetoxyhydroborate (23.15 g) was added to the mixture in ice-bath and the mixture was stirred at RT overnight and quenched with saturated NaHCO3 solution. The organic layer was dried with anhydrous Na2SO4, filtered and the filtrate evaporated in vacuo to give the title compound (22.17 g) as a syrup. MS (ESI): C18H26FN304requires 367; found 368 {M+H]., 169447-70-5
The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
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