Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A suitable commercial phenylpiperazine (2.00-5.10 mmol), K2CO3 (0.9-2.00 g) and acetone (7-16 mL) were stirred and refluxed for 30 min. Then, correspondingly substituted bromopentyl 3-benzyl-5,5-hydantoin derivatives 37-39 (2.20-5.70 mmol) in acetone (9-20 mL) were added and the mixture was refluxed for 6 h, left at room temperature overnight and separated from the inorganic precipitate by filtration. The solvent was evaporated from the filtrate. The pure product (14a-24a) was obtained from the residue using method C or D., 115761-79-0

The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Handzlik, Jadwiga; Bojarski, Andrzej J.; Sata?a, Grzegorz; Kubacka, Monika; Sadek, Bassem; Ashoor, Abrar; Siwek, Agata; Wi?cek, Ma?gorzata; Kucwaj, Katarzyna; Filipek, Barbara; Kie?-Kononowicz, Katarzyna; European Journal of Medicinal Chemistry; vol. 78; (2014); p. 324 – 339;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of lie (9.54 g, 74.4 mmol) and K2C03 (1 .7 g, 85.1 mmol) in DMF (60 mL) 1 -fluoro- 2-nitrobenzene lb (10.0 g, 70.9 mmol) was added at 25qC. Obtained reaction mixture was stirred at 50 C for 17 h and then water (200 mL) was added. The product was extracted to EtOAc (3 x 150 mL), combined organic layers were washed with water (3 x 100 mL) and brine (2 x 100 mL), dried over MgS04, and solvent was evaporated to afford the title compound Illc as orange oil which solidified upon standing. Orange crystals (17.4 g, 99% yield): H NMR (CDCI3, 500 MHz) 5 2.13 (s, 3H), 3.05 (m, 4H), 3.62 (m, 2H), 3.77 (m, 2H), 7.10-7.17 (m, 2H), 7.51 (m, 1 H), 7.80 (m, 1 H); MS (ESI) mlz. 250 [MH]+., 13889-98-0

13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; LEK PHARMACEUTICALS D.D.; ZUPANCIC, Borut; WO2015/107057; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

300 mg (0.86 mmol) der Verbindung aus Beispiel XVI werden in 8 ml 2-Ethyl-1- hexanol suspendiert und mit 266 mg (1.73 mmol) 1-Cyclopentylpiperazin und 0.75 ml (4.31 mmol) N, N-Diisopropylethylamin versetzt. Es wird ueber Nacht bei [150C] geruehrt. Nach dem Abkuehlen wird die Reaktionsloesung ueber eine MPLC gereinigt (Laufmittel : Dichlormethan-Methanol 10 : 1 + [1%] konzentrierter Ammo- niakloesung). Es werden 216 mg (52 % d. Th. ) Produkt erhalten. ‘H-NMR (400 MHz, DMSO-d6) : [8] [=] 1.28-1. 41 (m, 2H), 1.44-1. 55 (m, 2H), 1.57- 1.68 (m, 2H), 1.70-1. 85 (m, 2H), 2.43 (br. s, [5H),] 3.41 (br. s, 4H), 5.39 (s, 1H), 6.04 br. s, 2H), 6.97 (d, [2H),] 7.36 (dd, 1H), 7.45 (t, 1H), 8.23 (dd, 1H), 8.34 (d, 2H), 9.28 (s, [1H)] LC-MS (Methode 7) : [RT =] 2. [38] min MS (ESIpos) : [M/Z =] 466 [(M+H) +], 21043-40-3

The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER AKTIENGESELLSCHAFT; WO2003/106450; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred reaction mixture of XXVII (0.31 g, 0.99 mmol), V (0.27 g, 1 mmol), HATU (0.76 g, 2mmol) & DIPEA (0.646 g, 5 mmol) in DMF (5 mL) at RT for 16 h. Reaction mixture was diluted withwater and extracted with ethyl acetate (50 mL X 3), organic layer was washed with saturated brine solution(50 mL X 3), combined organic layer dried over anhydrous sodium sulphate, concentrated under vacuumto obtain crude which was purified by column chromatography using 100-200 silica gel (Eluent system-1% to 10 % MeOH: DCM) to obtain desired product XXVIII (0.200 g, 35%).LCMS: 575 [M+1]+

694499-26-8, As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

182618-86-6, 1-Boc-4-(4-Nitrophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1 equiv of 43 dissolved in methanol (anhydrous) and 10% of 10% Pd/C was added under a hydrogen atmosphere and allowed to stir overnight at room-temp. Reaction was filtered through a pad of celite and concentrated to give a blue/purple oil. The oil was brought up in DCM acidified using 1 M HCl and organic wash was removed. The aqueous was neutralized with sat’d sodium bicarbonate and washed 3 times with DCM, dried with sodium sulfate, filtered and concentrated and resulted in a pale red oil, 72% yield. MS (ES) 277.8 [MH+].

182618-86-6, 182618-86-6 1-Boc-4-(4-Nitrophenyl)piperazine 3380696, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; Castelhano, Arlindo; McKibben, Bryan; Steinig, Arno; US2003/229067; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,630125-91-6

General procedure: To a solution of 76 45 (30mg, 0.07mmol) in 77 DMF (5mL) were added 78 methylamine hydrochloride (5.4mg, 0.08mmol), 79 HATU (41.8mg, 0.11mmol) and DIEPA (18.1mg, 0.14mmol). The resulting mixture was stirred at room temperature for 2h. Then it was diluted with EtOAc (50mL), washed with water (100mL¡Á3) and brine (100mL). The organic layers were dried over anhydrous sodium sulfate and concentrated. The residue was diluted with DCM (1mL) and CF3COOH (0.5mL). The reaction mixture was stirred at room temperature for 4h and then the pH value was adjusted to 12 with saturated sodium bicarbonate. The mixture was extracted by 80 EtOAc (50mL) and washed with water (50mL¡Á2) followed by brine (50mL). The organic layers were dried over sodium sulfate, filtered, concentrated and purified by silica gel column chromatography (eluting with 0-5% MeOH in 81 DCM) to afford 82 9 (12.9mg, 52%) as a yellow solid.

As the paragraph descriping shows that 630125-91-6 is playing an increasingly important role.

Reference£º
Article; Liu, Xuesong; Wang, Beilei; Chen, Cheng; Jiang, Zongru; Hu, Chen; Wu, Hong; Zhang, Yicong; Liu, Xiaochuan; Wang, Wenliang; Wang, Junjie; Hu, Zhenquan; Wang, Aoli; Huang, Tao; Liu, Qingwang; Wang, Wei; Wang, Li; Wang, Wenchao; Ren, Tao; Li, Lili; Xia, Ruixiang; Ge, Jian; Liu, Qingsong; Liu, Jing; European Journal of Medicinal Chemistry; vol. 160; (2018); p. 61 – 81;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (3R)-3-methyl-6-(oxiran-2-yl)-3,4-dihydro-1H-isochromen-1-one (325 mg,1.59 mmol) and tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (345 mg, 1.59 mmol dissolved in EtOH(7mL) was heated in a sealed tube to 155C for 3 hours in the microwave. The reaction was cooled and concentratedto give crude product which was purified via MPLC (40-100% EtOAc/Hexane) to give the title compound as a mixtureof diastereomers., 314741-40-7

314741-40-7 (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 24820294, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

2.6 g of 3-oxetanone, 1.0 g of sodium cyanoborohydride and 0.16 ml of acetic acid are added to a solution of 2.0 g of benzyl piperazine-1-carboxylate in 20 ml of acetonitrile and then stirred for 16 hours at RT. The reaction mixture is diluted with water and filtered through a Chem Elut.(R). cartridge, eluting with DCM. The combined organic phases are dried over MgSO4 and the solvent is evaporated under vacuum. The residue is purified by preparative HPLC and 1.7 g of a white solid is obtained.

31166-44-6, The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI; US2012/277205; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8,694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add (3-((3-(pyridin-3-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)thio)propanoic acid to a round bottom flask (50 mg) followed by N,N-dimethylformamide (5 ml), 4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (42 Mg), 2-(7-oxobenzotriazole)-N,N,N’,N’-tetramethylUrea hexafluorophosphate (74 mg) and triethylamine (0.05 ml). The reaction system was stirred at room temperature for 14 hours under argon atmosphere. anti-After completion, the solvent was evaporated to dryness under reduced pressure. Organic phase with water,After washing with saturated brine, it was dried over anhydrous sodium sulfate. The organic phase is filtered and evaporated to dryness under reduced pressure to give a crude material.Alkane (5 mL) was added in trifluoroacetic acid (1 mL). The reaction system was stirred at room temperature for 14 hours under argon atmosphere. After the reaction,The solvent was evaporated to dryness under reduced pressure and the mixture was diluted with water and then neutralized with saturated sodium hydrogen carbonate. Aqueous phase acetic acidThe organic layer was washed with water and saturated brine and dried over anhydrous sodium sulfate. The organic phase is filtered and steamed under reduced pressureAfter drying, get a rough product. The crude product was purified by purified silica gel column chromatography to afford purified compound 173.

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Hefei Matter Sciences Institute; Liu Jing; Liu Qingsong; Liu Xuesong; Wang Beilei; Jiang Zongru; Yu Kailin; Chen Cheng; Zou Fengming; Liu Qingwang; Liu Xiaochuan; Wang Wei; Wang Wenliang; Hu Chen; Wang Wenchao; Wang Junjie; Wang Li; (82 pag.)CN109942544; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.

Step B 4-t-Butoxycarbonyl-2-ketopiperazine A mixture of 500 mg (5 mmol) of piperazinone, 1.2 g (5.5 mmol) of t-butyldicarbonate and 2 g of sodium chloride in 7.5 mL of water and 10 mL of chloroform was heated to reflux 4 hrs. The reaction mixture was cooled to room temperature and extracted with ethyl acetate. The combined ethyl acetate extracts were dried over anhydrous magnesium sulfate. Solvent removal gave a crude product which was purified on silica gel using 5% methanol in ethyl acetate as solvent to give 925 mg of the desired carbamate lactam as white solid. 1 H NMR (CDCl3): 1.46(s,9H); 3.37(m,2H); 3.62(m,2H); 4.08(s,2H), 5625-67-2

The synthetic route of 5625-67-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck & Co., Inc.; US5629322; (1997); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics