244132-27-2, (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of (S)-l-[((9H-Fluoren-9-yl)methoxy)carbonyl)-4-(tert- butoxycarbonyl)piperazine-2-carboxylic acid (0.27 g, 1.0 mmol), tert-butyl [2- (aminomethyl)-4-chlorobenzyl]carbamate (0.5 g, 1.10 mmol), HOBT (0.135 g, 1 mmol), and EDOHC1 (0.25 g, 1.30 mmol) in anhydrous DMF (3 mL) was stirred under nitrogen at room temperature for 16 h. The reaction mixture was quenched with water (10 mL), diluted with EtOAc (25 mL) and washed sequentially with saturated aqueous aHC03 solution (25 mL) and brine solution (25 mL). The organic layer was separated, dried over anhydrous Na2S04, filtered and concentrated. The residue was purified by reverse phase combiflash column chromatography (CI 8; eluent: 10-100percent acetonitrile: water) to afford the title compound (0.61 g) as white solid.
244132-27-2, As the paragraph descriping shows that 244132-27-2 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; BLIZZARD, Timothy Allen; BIFTU, Tesfaye; WO2013/148478; (2013); A1;,
Piperazine – Wikipedia
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