5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5317-33-9
DIAD (2.6 g, 13 mmol) was added dropwise to a solution of tert-butyl 4- (4-hydroxyphenyl) piperazine-1-carboxylate (3 g, 11 mmol) , 3- (4-methylpiperazin-1-yl) propan-1-ol (2.5 g, 16 mmol) and PPh3(4.3 g, 16 mmol) in THF (50 mL) . The resulting mixture was stirred at rt overnight. The solution was added with water (20 mL) , extracted with ethyl acetate (30 mL) and washed with brine (20 mL) . The organic layer was dried, concentrated and purified by column chromatography (DCM: MeOH = 15: 1) to get the desired product as a colorless oil (3.5 g, 78%) .1H NMR (400 MHz, DMSO-d6) delta 6.88 (d, J = 8.0Hz, 2H) , 6.81 (d, J = 8.0Hz, 2H) , 3.90 (t, J = 8.0Hz, 2H) , 3.44 (t, J = 4.0Hz, 4H) , 2.94 (t, J = 4.0Hz, 4H) , 2.38-2.30 (m, 10H) , 2.14 (s, 3H) , 1.82-1.79 (m, 2H) , 1.41 (s, 9H) ppm. MS: M/e 419 (M+1)+
The synthetic route of 5317-33-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BEIGENE, LTD.; ZHANG, Guoliang; SUN, Hanzi; ZHOU, Changyou; (253 pag.)WO2020/20097; (2020); A1;,
Piperazine – Wikipedia
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