With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-86-3,(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 122 and 123 (-0.216 mmol) in dioxane (3 ml_) was added (S)~N-Boc-2-benzylpiperazine (0.07 g, 0.254 mmol) and diisopropylethylamine (0.077 ml_, 0.443 mmol). The reaction mixture was heated at 600C for 1 hour. The organic solvent was evaporated under reduced pressure. The crude product mixture was purified by RP-HPLC to yield 3-(3-methylindazol-5-yl)-5-[(S)-4-Boc-3-benzylpiperazin-1-yl]- [1 ,2,4]triazine 124 (0.012 g, 0.025 mmol) and 6-chloro-3-(3-methylindazol-5- yl) )-5-[(S)-4-Boc-3-benzylpiperazin-1-yl]-[1 ,2,4]triazine 125 (0.02 g, 0.038 mmol).
169447-86-3, The synthetic route of 169447-86-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SCHERING CORPORATION; WO2006/81230; (2006); A2;,
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