With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
General procedure: In a 25 mL two necked round bottom flask, azole (1 mmol), amine (2.0 mmol), Cu(acac)2 (52.6 mg, 20 mol %), and 5 mL xylene were added. The above mixture was kept under reflux condition and then molecular oxygen was bubbled into the reaction mixture till the completion of reaction. The progress of reaction was monitored using gas chromatography. After completion of the reaction, the reaction mixture was filtered through celite bed. The organic solvent was removed under reduced pressure. The reaction mixture was analyzed using gas chromatography (Perkin Elmer, Clarus 400) equipped with a flame ionization detector (FID) and capillary column. The crude product was purified by column chromatography (silica gel, 100-200 mesh; petroleum ether/ethyl acetate, 90:10) to afford pure products. All the prepared compounds were confirmed by comparing with their authentic samples and were characterized by GC-MS (Shimadzu QP 2010), 1H NMR (Varian 500 MHz).
13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Wagh, Yogesh S.; Bhanage, Bhalchandra M.; Tetrahedron Letters; vol. 53; 48; (2012); p. 6500 – 6503,4;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics