278788-66-2, (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: tert-butyl (3R)-4- [2-(3-cyano-4-fluoro-2-methylphenyll)-2-hydroxylethyli -3-(hydroxymethyl)piperazine- 1 -carboxylate: 6-Fluoro-2-methyl-3- (2-oxiranyl) benzonitrile(prepared as described above, 4.80 g, 27.1 rnmol) and (R)-4-N-BOC-2-hydroxymethyl-piperazine (8.79g. 40.6 rnmol) were suspended in EtOH (3OmL) and heated in a microwaveapparatus at 150 C for 1 h. The reaction mixture was cooled and evaporated to dryness. Theresidue was purified by chromatography through a 330 g ISCO Redi-sep column eluting with ethyl acetate to 5% MeOH/ ethyl acetate to yield the title compound. LC-MS: M+1= 394;
278788-66-2, As the paragraph descriping shows that 278788-66-2 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DEJESUS, Reynalda, Keh; FRIE, Jessica, L.; PIO, Barbara; TANG, Haifeng; WALSH, Shawn, P.; WO2014/99633; (2014); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics