109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
109384-27-2, To a mixture of 6-chloro-3-nitro-2-picoline (500 mg, 2.84 mmol) and 1-methyl-piperazin-2-one hydrochloride (535 mg, 3.55 mmol) in dioxane (15 ml) were added Cs2CO3 (1215 mg, 3.69 mmol) and xantphos (25.4 mg, 0.043 mmol). The mixture was degassed with Argon for 5 min, then Pd(OAc)2 (6.37 mg, 0.028 mmol) was added. The light brown suspension was heated up to 1 100C and stirred for 18h. The reaction mixture was concentrated then diluted in EtOAc/NaHCO3 aq. sat. soP. The aqueous layer was extracted twice with EtOAc. The combined organics were washed with brine, dried (Na2SO4) and after filtration, the solvent was removed under reduced pressure and the crude product was dried under high vacuum (500C). Purification was done by chromatography on silica gel (eluting with DCM / MeOH; 99/1 then 98/2) to obtain the title compound as a pink solid (347mg). (HPLC: tR 5.319 min (Method B); M+H = 251.2 MS-ES)
109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVARTIS AG; FURET, Pascal; IMBACH, Patricia; MAH, Robert; STAUFFER, Frederic; WO2010/139747; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics