208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 117(R)-ethyl 1-((1-(2-(4-(tert-butoxycarbonyl)piperazin-1-yl)ethyl)pyrrolidin-3-yl)methyl)-6-(6-(3-ethylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylateTo a vial was charged (R)-ethyl 6-(6-(3-ethylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-yl)-4-oxo-1-(pyrrolidin-3-ylmethyl)-1,4-dihydroquinoline-3-carboxylate (Intermediate 115) (50 mg, 0.081 mmol), tert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate (23 mg, 0.090 mmol) and potassium carbonate (15 mg, 0.11 mmol) in anhydrous acetonitrile (2 mL) and the resulting mixture was stirred at 60-65 C. for 1.5 hours. The mixture was then diluted with saturated sodium bicarbonate and the product extracted with ethyl acetate. The organics were dried over sodium sulfate, concentrated, and purified with another lot (1.3 mmol) by Analogix eluting with dichloromethane/methanol.MS (ESP): 827.1 (MH+) for C40H49F3N8O6S, 208167-83-3
As the paragraph descriping shows that 208167-83-3 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; US2010/317624; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics