With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.
Intermediate 3 (2.63 g, 13.1 mmol) was dissolved in DCE (60 mL). Cyclobutanone (1.38 g, 19.7 mmol) and acetic acid (0.75 mL, 13.1 mmol) were added and the mixture stirred at rt for 30 min. NaBH(OAc)3 (4.18 g, 19.7 mmol) was added portionwise and the mixture was stirred at rt overnight. Sat. Na2CO3 (50 mL) was added and the aq. layer was extracted with DCM (3¡Á75 mL). The combined organic phases were dried over Na2SO4, filtered and concentrated under reduced pressure to provide 2.58 g title compound (77%) as an oil. 1H NMR (300 MHz, CDCl3) delta ppm 0.97 (d, J=6.4 Hz, 3H) 1.45 (s, 9H) 1.61-1.70 (m, 2H) 1.81-1.91 (m, 1H) 1.93-2.00 (m, 2H) 2.03-2.14 (m, 2H) 2.41-2.51 (m, 1H) 2.58-2.65 (m, 1H) 2.94-3.05 (m, 1H) 3.06-3.16 (m, 1H) 3.29-3.58 (m, 3H).
163765-44-4, The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; US2010/216812; (2010); A1;,
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